In 1992 Aprilia won its first World Speed Championship: just a few days after Tommy Avhala became World Trial Champion with the Aprilia Climber (where Aprilia was Champion Maker), Alex Gramigni won the World Championship in the 125cc class, clearly beating Gresini and Waldmann on Honda: the Tuscan rider won in Malaysia and Hungary, while Casanova was successful in Germany.

The 250cc bike, an evolution of the '91 model, immediately set off on the right foot: at Jerez, the fourth Grand Prix of the season, Reggiani (still flanked by Chili and Massimiliano Biaggi as "externals"), dominated the field.

The various world races continued with Aprilia always among the leaders, until the apotheosis came at Hockenheim, with Chili first, Biaggi second and Reggiani third; not only, but Biaggi had won the pole position and Reggiani the fastest lap in the race.

Chili also won at Assen and Donington, Reggiani at Magny Cours; the golden season closed with another hat trick at Kyalami, with Biaggi, Reggiani and Chili in that order.

Maurel won the European Championship in the 250cc class.